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This is consistent with previous findings that -cell plasticity occurs in common forms of -cell dysfunction, and is caused by the downregulation of FoxO1 that follows hyperglycemia-induced oxidative stress 26

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[DOI] [PMC free article] [PubMed] [Google Scholar] 180.Obeidat M., Nie Y., Fishbane N., Li X., Bosse Y., Joubert P., Nickle D.C., Hao K., Postma D.S., Timens W., et al

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