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Segain JP, Raingeard de la Bltire D, Bourreille A, Leray V, Gervois N, Rosales C, et al

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Results show that NAC significantly reduces oxidative stress in NPC disease but has no effect on autophagic dysfunction-related cholesterol accumulation, thus failing in clinical trials ( 2.1 SQSTM1 SQSTM1 (sequestosome1, also called p62) is an autophagy adapter protein that participates in the degradation of protein aggregates and cytoplasmic bodies (Shin et al., 2020)

FIGURE 3 3.1 Single botanical drugs and monomers in DKD that regulate the AMPK/SIRT1/mTOR pathway to mediate autophagy Numerous TCMs and their active monomers, such as Rehmannia glutinosa (Gaertn.) Libosch