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PLoS One 2011;6:e26747
Wolf, Handbook of Vitamins , 4th ed, edited by Janos Zempleni, Robert B Rucker, Donald B McCormick, and John W Suttie, 2007, 593 pages, hardcover, $107.96
Aduhelm was tested in two such trials -- ENGAGE and EMERGE -- but these were discontinued in March 2019 after an independent data monitoring committee found that the medication didn't seem to be making enough of an impact
Tirzepatide, a dual-agonist peptide, has shown significant results with a 22.5% weight loss over 72 weeks at a 15 mg dose (Jastreboff et al., NEJM), making it one of the most effective therapies for obesity
