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Siyao L, et al

The chemical reactivities of iron and sulfur, together with variations in the composition, redox potential, oxidation state, physical accessibility of the cluster and effects of the local protein environment, enable these versatile cofactors to accept or donate single electrons, catalyze enzymatic reactions or function as regulatory proteins

The first reported GPX4 inhibitor RSL3 covalently interacts with selenocysteine, the active site of GPX4, to inhibit enzymatic activity of GPX4, thus inducing ferroptosis

Vascular endothelial growth factor receptor 1 signaling facilitates gastric ulcer healing and angiogenesis through the upregulation of epidermal growth factor expression on VEGFR1+CXCR4+ cells recruited from bone marrow