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Vitamin B12 is a powerhouse for energy production and maintaining a healthy nervous system

An increase in behavioral reactivity in an open field following early postnatal Mn exposure (2550 mg/kg/day orally) was associated with a reduction in evoked norepinephrine outflow, decrease in TH, DAT, NET, and D1 receptor protein levels in prefrontal cortex, in parallel with up-regulation of D2R protein levels and astrocyte reactivity assessed by GFAP (Conley et al., 2020)

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Furthermore, L-Carnitine plays a primary role in transporting long-chain fatty acids into mitochondria to produce cellular energy, while acetyl coA (a group of coenzymes that metabolise fatty acids) prevents further accumulation of fatty acids and protects the cellular membrane

Sirtuins are NAD-dependent