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The archetypal Fe-driven cycle illustrates this process:138140Fe0 + 2H+ Fe2+ + H2 (Corrosion)Fe2+ + H2O2 Fe3+ + OH + OH (Fenton Reaction)O2 + Fe3+ O2 + Fe2+ (HaberWeiss Cycle)Here, the regenerative cycling between Fe2+ and Fe3+ sustains ROS production with catalytic efficiency

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Thus, it is well known in the art that the N-terminal methionine encoded by the translation initiation codon generally is removed with high efficiency from any protein after translation in all eukaryotic cells