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Description
Differences in foot and forearm skin microcirculation in diabetic patients with and without neuropathy

The amygdala hyperactivation, excessive sympathetic nervous system arousal, and impaired fear extinction that characterize anxiety disorders respond to different peptide targets than the anhedonia, BDNF deficits, and hippocampal atrophy more central to depression

They demonstrated that a three-week supplementation of 1000 mg NR per day increased muscle NAD + metabolome, specifically NAAD and products of NAM clearance pathways, yet NAD + levels were not altered

doi: 10.1096/fj.201901192R

It is a different category of treatment entirely
