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The current recommended therapeutic strategy for ischemic stroke involves thrombolysis, via recombinant tissue plasminogen activator (rtPA) injection within 4.5 h post onset, 149,150,151,152 alongside mechanical thrombectomy within 24 h post onset

Iron increases diabetic kidney injury by increasing oxidative/nitrifying stress and decreasing antioxidant capacity

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Finally, although the total brain lipid content may decrease with age, the enzymes responsible for incorporating PUFAs into membrane phospholipids remain active, ensuring the continued presence of the necessary substrates for the final execution step of ferroptosis (75)

Finally, a critical layer of defense exists in the meticulous regulation of transition metals, particularly iron