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Metformin-associated lactic acidosis: current perspectives on causes and risk

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These mechanisms will lead to the decline of liver detoxification function, and then lead to specific liver injury (Aljobaily et al., 2020

Strategies aimed to increase cytosol GSH (e.g., NAC) may not be an optimal approach for boosting mGSH and therefore for treatment of SH or AD, as it would result in mainly increasing cytosol GSH without replenishing mGSH levels A new approach has been exploited recently in several contexts by the development of a series of cationic antioxidants targeted to mitochondria, including derivatives of the endogenous antioxidants ubiquinol (MitoQ), alpha-tocopherol (MitoVit E), and of the synthetic spin trap PBN (MitoPBN

Flow cytometric detection of hydrogen peroxide production induced by doxorubicin in cancer cells