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When SIRT6 is overexpressed, it impaired the JAK2/STAT3 axis, leading to apoptosis and reduced cell proliferation in CRC cells
Genetic or pharmacologic loss of FABP5 disrupts mitochondrial cristae structure, resulting in release of mtDNA, and triggers cGAS-STING-dependent type I interferon signaling, which promotes Treg cell suppressive function and enhances antitumor immunity (101) (Figure 2)
Targeting acetylcholinesterase and butyrylcholinesterase in dementia
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