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The functional impact of mitochondrial structure across subcellular scales

Once PUFA-containing phospholipids become integrated into cell membranes, they are highly susceptible to peroxidation

In the future, we plan to optimize expression conditions to improve yield and purity, facilitating advanced analyses such as structural studies using cryo-electron microscopy

Consistent with these gene expression and proteome changes, mouse brain metabolome analysis found that the ratio of C12-C18 long chain acylcarnitines to C6-C12 medium chain acylcarnitines increased with aging, suggestive of decreased long-chain fatty acid beta-oxidation in the aged brain (Borkowski et al., 2025)

7 Systemic metabolic disorders that contribute to Alzheimer's disease 7.1 Diabetes, insulin resistance and metabolic syndrome The complex interplay of diabetes, dyslipidemia, obesity, and hypertension in clinical settings makes it challenging to pinpoint their individual roles in pathology