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Cox proportional hazards analyses were performed to examine the association between GGT level and mortality risk, adjusted for age and sex (model 1), lifestyle behaviors (smoking status, alcohol consumption, and physical activity), and income level (model 2) and additionally BMI, ALT, comorbidities (diabetes mellitus, hypertension, and dyslipidemia), and CCI score (model 3)

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If COMT is not working, you can get oestrogen detoxification issues, and increased oestrogen can lead to increased histamine