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Moreover, NADH is necessary for preserving cellular bioenergetics, genomic integrity, and other important physiological pathways 73

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In normal physiologic state, the brain parenchyma is only subject to nascent immune surveillance, however during inflammation, the elevated pro-inflammatory markers induce the increased expression of adhesion molecules like intercellular adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule-1 (VCAM-1) on the endothelial cells of the BBB (Varatharaj and Galea, 2017

These Ld-IL2-induced metabolic changes might be pivotal in modulating immune responses, particularly in enhancing the function of regulatory Tregs, which are vital in maintaining immune tolerance