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This evolution in medicine also presents challenges, such as the need for robust data integration, ethical considerations, and the development of cost-effective strategies that can be widely implemented in clinical practice

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Consistently, APOC3 knockout mice had decreased TG concentration ( 30%) compared to wild littermates, while APOC3 transgenic mice showed increased serum TG level (+ 200% to 2000%) [46, 47]

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The majority of these cut-points correspond to desirable concentrations from guidelines and consensus statements

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