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Administration of exogenous insulin is the main treatment for T1DM patients

for instance, HSF1 cooperates with ATF5 to potentiate CHOP activity (Katiyar et al., 2020)

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Ari and colleagues showed that this simplified metabolic treatment delayed motor symptoms and increased survival in SOD1 G93A mice (Ari et al., Dichloroacetate Dichloroacetate (DCA) is a pyruvate dehydrogenase (PDH) kinase inhibitor (Whitehouse et al., 1974)