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Tranfield, A.L

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Acknowledgements We thank all Yan Lab members for their comments on the manuscript

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Abbreviations ED: Energy drinks B2: Riboflavin B3: Niacin B6: Pyridoxine B8: Inositol B12: Cyanocobalamin Vit C: Ascorbic acid Vit D: Cholecalciferol D2: Ergocalciferol D3: Cholecalciferol WHO: World Health Organization DGL: Glucuronolactone C6H10O5: Maltodextrins B2: Riboflavin B3: Niacin B6: Pyridoxine CVD: Cardiovascular diseases B8: Inositol B12: Cyanocobalamin Ca: Calcium LDL: Low-density lipoprotein Fe: Iron Cr: Chromium Zn: Zinc Mn: Manganese Mo: Molybdenum RCTs: Randomized controlled trials IARC: International Agency for Research on Cancer CABs: Caffeinated alcoholic beverages FDA: Food and Drug Administration PCOS: Polycystic ovary syndrome RNA: Ribonucleic acid CNS: Central nervous system DNA: Deoxyribonucleic acid LDL: Low-density lipoprotein SOD: Superoxide dismutase CAT: Catalase GSH: Glutathione GST: Glutathione S -transferase DM: Diabetes mellitus T2D: Type 2 diabetes MKI 67: Marker of proliferation Ki-67 Bcl-2: B-cell lymphoma 2 c-myc: C-myelocytomatosis p53: Tumor suppressor protein p27: Cyclin-dependent kinase inhibitors EFSA: European Food Safety Authority AFSSA: Agence Franaise de Scurit Sanitaire des Aliments FSSAI: Food Safety and Standard Authority of India JECFA: Joint FAO/WHO Expert Committee on Food Additives ADI: Acceptable daily intake References Ab Qayoom N, Zafar T, Vinoy KS (2018) Health implications associated with aspartame consumption: a substantial review