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Geraldo, Luiz Henrique

10.1038/ncb2012 Nat

In response to various mitochondrial stressors, such as hypoxia, loss of mitochondrial membrane potential, and oxidative stress, mitophagy receptor proteins are engaged in the selective destruction of damaged mitochondria through their interactions with the essential autophagy protein LC3 [15, 105]

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Because of its ability to assist in the regulation of oxidative stress, production of cytokines, and overall immune response, the use of GSH and precursors like NAC have become increasingly popular as potential medicinal agents for autoimmune and neurodegenerative diseases such as AD, PD, and MS that involve inflammation and unregulated immune response (Tieu et al., 2023