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You're more likely to get HSV if you: Were assigned female at birth (AFAB) Have had multiple sex partners Started having sex at a young age Have a history of STD or STI Have a weakened immune system Don't use condoms and dental dams for intercourse and oral sex You're most at risk of complications from the virus if you have a weakened immune system because you: Have HIV or AIDS Have an autoimmune condition, such as eczema, rheumatoid arthritis, or systemic lupus erythematosus Take chemotherapy drugs because you have cancer Take antirejection medicine because you had an organ transplant Oral Herpes Treatment at Home To ease your pain and discomfort, try some of these remedies: Use over-the-counter (OTC) cold sore medicines