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doi:10.1016/b978-0-12-815849-4.00001-3

Macrophages and dendritic cells produce IL-1 through macro-molecular complexes called inflammasomes, including the major element present in the pulmonary tissue and the nucleotide-binding oligomerization domain (NOD)-like receptor pyrin domain-containing protein 3 (NLRP3) inflammasome [20]

The transactivation potential of NF-B is increased by the phosphorylation of the NF-kB p65 subunit [25]

J Pathol Transl Med

Takeaway While glutathione is a potent antioxidant with many health benefits, its use as a skin-lightening agent is not supported by scientific evidence and may be associated with severe and life-threatening side effects