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These observations were also made in conjunction with the measurement of other indicators of OXPHOS dysfunction, such as lower cellular ATP levels [with ISO (84, 88), SEV (56, 91, 92, 94), PPF (89) and KET (56)] and oxygen consumption rate [with SEV (87, 91)] indicating reduced bioenergetic capacity of the mitochondria in rodent models

As a result, the BMSCs in the NP-like composite hydrogel network were highly energetic and uniformly distributed, and the scaffold could maintain the height of the rat IVD and generate new ECM

10.1016/j.nantod.2012.01.002 99 PanX.VeroniainaH.SuN.ShaK.JiangF.WuZ.et al (2021)

To match this call for inclusivity, trial design must also evolve, adopting adaptive and master protocols that reflect the complexity of neurodegeneration in the real world

TRPV1 agonists mitigate myocardial I/R injury by preserving mitochondrial membrane potential and ATP synthesis [141]
