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Additionally, studies reveal that those with family records of oily skin can have more active sebaceous glands, which would result in more significant amounts of oil production

doi:10.1016/S0736-0266(03)00110-4 Goldstein AL, Hannappel E, Sosne G, Kleinman HK

Extensive studies have been already undertaken to analyse the effects of NSAIDs at the molecular level besides designing new combinatorial formulations in the form of NSAID-prodrugs with enhanced efficacy

I touched on this briefly earlier, but its worth mentioning again

The furthest from replicating human pathophysiology would be other species such as rats, which are not a good model for APAP hepatotoxicity