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Upon cuprizone treatment Tyro3 gene expression was down-regulated and seems to coincide with oligodendroglial loss, while Axl and Mer were found on activated microglia (Binder et al., In addition, in this model microglia seem not to be assigned to a certain phenotype characteristic either for de- or remyelination since most of the genes that were regulated showed an unidirectional up-regulation or down-regulation throughout the de- and remyelination processes (Olah et al., 2012) In respect to the M1/M2 classification it seems that the microglia population in the cuprizone model is either heterogeneously composed of both M1 and M2 phenotypes or microglia display an intermediate status

Tillemans et al., 2014

Molecular interaction studies

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