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This modification enhances NNTs affinity for its substrate NADP+, promoting NADPH synthesis, maintaining ironsulfur cluster homeostasis, lowering intracellular ferrous iron levels and lipid peroxidation, and thereby protecting tumor cells from ferroptosis (118)

Supporting this, the tracer experiments in mice show that NMN is first converted into either NAM or NR before NAD + synthesis in most tissues 69

Cell Biol Int 40 , 534548, doi: 10.1002/cbin.10590 (2016)

Ferroptosis is defined by excessive intracellular iron accumulation due to metabolic imbalance, where Fe 2+ generates a large amount of hydroxyl radicals (OH) through the Fenton reaction (Figure 2)

There is no need for H 2 , although it is not detrimental to growth