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The basic molecular machineries of the HSR and UPR ER have been elucidated, but how the UPR ER interacts with other cellular stress response pathways to maintain cellular proteostasis remain a subject of ongoing research

Expi293 cells (ThermoFisher, A14527) were maintained in Expi293 medium (ThermoFisher) supplemented with 10% HI-FCS, 25 g/mL streptomycin and 25 U/mL penicillin (ThermoFisher)

(Note: Carnitine is only available in Lipo-Mino-Mix-C under Patient Prescriptions) Dosage, Concentration, Route of Administration Dosage: Seek advice from a licensed physician, medical director, or other healthcare provider Concentration (per mL): B6 2mg, Methionine 12.4mg, Inositol 25mg, Choline 25mg, B1 50mg, B2 5mg, Carnitine 125mg** (Carnitine is only available in Lipo-Mino-Mix-C) Route of Administration: IM/SubQ Available Sizes: 10mL and 30mL Resources: Tutorial: How to Open Your Medication Vial Not sure how to administer this medication

457 Iron, an important modulator of oxidative stress, also contributes to the dystrophic pathology