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Wnt signaling in stem cell regulation and tissue regeneration In contrast to the Wnt/Frizzled/-catenin axis, which is evolutionarily conserved from early multicellular animals and onward, the R-spondin/Lgr gene families are primarily a vertebrate specific evolutionary addition

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Pathogenic, glycolytic PD-1 + B cells accumulate in the hypoxic RA joint

Additional support by the Felix and Carmen Sabates Missouri Endowed Chair in Vision Research and a Challenge Grant from Research to Prevent Blindness is gratefully acknowledged