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PMX500FI, a synthetic carnitine-conjugated -lipoic acid derivative, can cross the bloodretinal barrier and improve mitochondrial function [321]

Without L-carnitine, these dietary fats cannot enter the mitochondrial matrix to undergo beta-oxidation, the biochemical process that breaks down fats to generate adenosine triphosphate (ATP), the universal energy currency of the human body
Given that the biosynthesis of these octadecanoids is COX-independent, this finding may explain why COX-inhibitors (e.g., ibuprofen) only show weak antinociceptive effects in UVB-induced mechanical allodynia in rodents

He called to commend us on our Fall edition, to share his perspectives on long Covid, and to reflect on the crazy state of our world

Beal MF (2003)
