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It is produced in the respiratory tract, binds and/or traps bacteria, viruses, and particulate matter inhaled from the environment, and facilitates their removal by the process of mucociliary clearance (MCC), which relies upon 1) optimal expansion of mucus after secretion, 2) proper hydration of the airway to provide sufficient epithelial surface liquid (ESL), also known as airway surface liquid (ASL), to allow for full extension of the cilia, 3) proper ciliary beating to move mucus from the small lower airways into the trachea, and 4) swallowing and clearance through the gastrointestinal tract [26]

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