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A study of rats exposed chronically to OTA, even at doses that resulted in 25% of the animals developing kidney tumor formation, the gene expression profile showed down-regulation of the antioxidant genes [73]

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In fat cells, 5-amino-1MQ lowered the NNMT byproduct 1-methylnicotinamide (EC50 near 2.3 micromolar) and cut fat storage, without disturbing the other enzymes in the NAD+ salvage pathway

This suggests that curcumin can support the bodys natural ability to produce glutathione, especially in conditions of oxidative stress