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The stimulant effects of phentermine (increased heart rate, elevated blood pressure) combined with the cardiovascular changes produced by GLP-1 medications created a physiological profile that researchers flagged for further investigation

This is different from exogenous GH or GHRH-style peptides, which raise systemic GH and affect every tissue

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Reviews and case reports show good results for pain relief and improved function, but many of the studies are small, industry-funded, or do not follow patients for long periods (Williamson et al., 2021