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Moreover, baseline CRP has been an independent predictor of 5-year overall survival in cases with malignant pleural mesothelioma with patients who underwent extrapleural pneumonectomy [808]

Familial chylomicronemia syndrome is a rare genetic disorder estimated to affect 1 to 2 individuals per million and characterized by hypertriglyceridemia, which is caused by mutations in LPL or genes that regulate LPL function which include but are not limited to APOC2, APOA5, GPIHBP1, and lipase maturation factor 1 (LMF1) [19,20]

Historical background of RNA-based therapeutics Significant advancements in gene sequencing technology have been made after the completion of the human genome project in 2003, which deepened our understanding of genetic causes for different diseases (Goodwin et al., 2016) and paved the way for the development of RNA-based therapeutics, which target disease-related genes that could not be targeted by conventional drugs, small molecules or protein-based drugs (Kaczmarek et al., 2017)