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This study reinforced the concept that massive doses of B12whether delivered via injection, nasal drop, or highly concentrated sublingual liquidare required to force the vitamin across the blood-brain barrier via passive diffusion to relieve localized central nervous system deficiencies

Females are generally carriers, but it often does not produce symptoms because they have two X chromosomes

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Brain 142:391411 Sun HL, Deng DP, Pan XH, Wang CY, Zhang XL, Chen XM, Wang CH, Liu YX, Li SC, Bai XY, Zhu W (2016) A sub-threshold dose of pilocarpine increases glutamine synthetase in reactive astrocytes and enhances the progression of amygdaloid-kindling epilepsy in rats

FASEB J 23:23742383 Meguid NA, Dardir AA, Abdel-Raouf ER, Hashish A (2011) Evaluation of oxidative stress in autism: defective antioxidant enzymes and increased lipid peroxidation