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Rodent models exhibit notable differences in lipid metabolism, immune regulation, and gut-liver interactions, which may compromise their translational value (Loomba et al
This approach provides a comprehensive assessment of OS, bridging the gap between fragmented biomarkers and their functional relevance (131)

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5.5 Metabolic regulation therapy Metabolic modulation therapy has demonstrated potential therapeutic value for a variety of diseases, including RA, by regulating cellular metabolic pathways, improving cellular energy metabolism under hypoxic conditions and reducing metabolic stress responses

10.3233/JAD-160533 J
