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while some studies indicate that higher PA intake may reduce obesity risk, others suggest an association with increased obesity likelihood 28,29

Beside lowering blood glucose, several mechanisms, including improved energy metabolism, vascular function, hemodynamic alterations, decreased oxidative stress, and reduction in inflammation, are proposed to mediate CV benefit of SGLT2 inhibitors

Allen, E.M

Gonzlez, G

Computational modeling and experimental validation demonstrate that epitalon binds specific nucleotide sequences including ATTTTC and ATTTG motifs found in telomerase gene promoter regions [3]
