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Although peripheral neuropathy is commonly thought to be driven by hyperglycemia and redox stress, recent studies have shown correlations between low l-serine levels and indicators of peripheral neuropathy

This initial functional assignment was based on a classification established for scorpion venom enzymes, and the following six functional classes are recognized: 1) toxic enzymes that are used in hunting and defense, 2) pre-digestive enzymes that break down tissue and support extra-intestinal digestion, 3) spreading factor enzymes that support the uptake of co-secreted toxins, 4) venom component activators that are involved in protein maturation, 5) preservative enzymes that defend the venom gland against noxious molecules, 6) multifunctional enzymes (Delgado-Prudencio et al., 2022)

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Amsterdam, The Netherlands: 2013

The pathogenesis of OA is highly complex, involving interactions among multiple factors such as abnormal mechanical loading, age-related metabolic changes, persistent inflammatory responses, dysregulated extracellular matrix(ECM) metabolism, and genetic susceptibility