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While beta-cell survival is an enigma left to be solved, up-to-date research using animal models and human islet cells has managed to shed light on novel drugs and transplant designs that can reasonably enhance beta-cell survival [125,126,127,128,129]

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Representative original magnification, 20, images were acquired for analysis of the cross-sectional area with a semi-automated ImageJ (National Institutes of Health) macro as previously described 77

MCE, HY-106376) and trolox (Sigma-Aldrich, 238813) were diluted in water at 100 mM and added at the indicated concentrations

8 , 346ra392 (2016)