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Description
Iron overload is a defining feature of ferroptosis, which promotes lipid ROS accumulation by producing hydroxyl and alkoxyl radicals through the Fenton reaction 13

(table S9)

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Each engages tendon healing through different molecular mechanisms

Based on the above, we believe that it would be useful to identify individuals with IR both before they develop HF and during the course of HF in order to attempt to prevent or, at least, slow down the negative progression of HF, including through interventions designed to counteract IR
