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Most animal models exhibit neuroprotective benefits between 5 mg/kg up to 50 mg/kg (Table 2)

Monitor for signs of allergic reactions such as swelling, redness, or discomfort

Introduction Drug hypersensitivity reactions (DHRs) encompass a broad spectrum of adverse drug reactions (ADRs) with heterogeneous clinical presentations and mechanisms ( Classification of drug hypersensitivity reactions ADRs are defined as unintended and noxious reactions to drugs that occur at doses normally used for prophylaxis, diagnosis, or treatment ( Currently, ADHRs are categorized primarily based on Gell and Coombs classification system into type I reactions (also known as immediate-type allergic reactions) mediated by immunoglobulin E (IgE) antibodies, type II reactions (also known as cytotoxic allergic reactions) elicited by immunoglobulin G (IgG) or M (IgM) antibodies, type III reactions triggered by immune-complex deposition, and type IV reactions (also known as delayed-type reactions) induced by cellular immune mechanisms ( ( Figure 1 )

However, in a pathological context, tau protein undergoes abnormal hyperphosphorylation, which leads to intracellular tau accumulation and the formation of neurofibrillary tangles in the brain

For microbial induction, neutrophils (1.5 10 5 cells per well) were co-cultured with E