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Bi-directional permeability assay with Caco-2 cells Compounds were tested in a Caco-2 cell bi-directional permeability assay using an established contract research organization (Cyprotex
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Ulanovskaya OA, Zuhl AM, Cravatt BF. NNMT promotes epigenetic remodeling in cancer by creating a metabolic methylation sink. Nat Chem Biol. 2013 May;9(5):300-6. doi: 10.1038/nchembio.1204. Epub 2013 Mar 3. PMID: 23455543; PMCID: PMC3631284
Patients receiving botulinum toxin, for example, for epiphora ceased therapy prior to entering the program
