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In 2017, Murata and collaborators reported that serum carnitine level was negatively correlated with severity of constipation in 27 patients

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The reaction is catalyzed by the carnitine acetyltransferase (CrAT, EC:2.3.1.7), which is present in many cell compartments, including the cytosol, the matrix or mitochondria and peroxisomes, as well as the endoplasmic reticulum and nucleus [5, 83, 106]

Biol Psychiatry 28 : 223230 Muscat R, Papp M, Willner P
Potent analgesic effects of GDNF in neuropathic pain states
