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REDEFINE2: Over 1,200 adults with T2DM and obesity/overweight achieved 15.7% weight loss after 68 weeks among adherent patients (3.1% with placebo)

Activity-dependent brain-derived neurotrophic factor signaling is required for the antidepressant actions of (2R,6R)-hydroxynorketamine

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It binds all five somatostatin receptors (sst1-5) with affinities comparable to somatostatin, but uniquely also activates the ghrelin receptor (GHSR-1a)

Diagnoses were confirmed by two endocrinologists using specific biomarkers, such as the levels of pancreatic autoantibodies, in accordance with the Chinese Type 1 Diabetes Guidelines and the American Diabetes Associations criteria