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The MHRA advises checking B12 levels if deficiency is suspected and considering periodic monitoring in at-risk patients, whilst generally continuing metformin therapy during investigation and treatment

In the United States, between 3 to 6 % of the population are vitamin B12 deficient and up to 20% have marginally depleted levels (3)

Draw the appropriate dose from the reconstituted vial using a 1mL syringe

Medications that are particularly susceptible to altered absorption kinetics include oral contraceptives, where delayed or reduced absorption could potentially compromise contraceptive efficacy

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