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10.1016/j.sjbs.2021.03.038 157 VojtechL.WooS.HughesS.LevyC.BallweberL.SauteraudR

doi: 10.1016/j.biopsych.2008.12.013 33 Montecino-RodriguezEClarkRGPowell-BraxtonLDorshkindK

Following granule exocytosis, perforin facilitates the delivery of granzymes into the cytosol of the target cell where they cleave numerous substrates, including caspases, resulting in the rapid induction of apoptosis 7,8

As a glutaminase inhibitor, CB-839 is highly sensitive to esophageal squamous cell carcinoma (ESCC), which is highly dependent on glutamine metabolism for energy, providing a new possibility for the treatment of ESCC [69]

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