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Experiments were performed at least three times with at least three technical replicates in each experiment

Nevertheless, attempts to develop melatonin as a contraceptive pill in combination with progestin have not been successful (58)

Then using a H 2 O 2 -induced senescent TM3 Leydig cell model, we found that FOXO4 maintains the viability of senescent Leydig cells and that the FOXO4 blocker FOXO4-DRI induces apoptosis in these senescent cells

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Because it is longacting and aggregationresistant, Cagrilintide enables chronic dosing protocols that more closely mimic prospective therapeutic scenarios