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On the contrary, there are no data to suggest that CRP is the direct cause of any disease, whereas CRP infused in relatively healthy human adults does not trigger any significant clinical, hematologic, coagulative, or biochemical alterations, or any increase in proinflammatory cytokines or acute phase proteins [113]

This effect is expected to be further magnified by the fact that increasing compaction should also reduce water infiltration into the bulk of the implant, which should increasingly confine drug release to the outer implant surface 7

Recent research has demonstrated that ApoC-III impacts TG-rich lipoproteins (TRL) metabolism, inflammation, atherosclerosis progression, glucose metabolism, and cardiovascular diseases 41

doi: 10.1016/j.tifs.2017.06.015 [DOI] [Google Scholar] 96.Tian KZ, Cao CC, Nie XM, Wang W, Han CQ