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Results in cerebrovascular disease
Depletion of Cu using chelators has been shown to delay cancer metastasis by inhibiting the vascularization of lesions across several animal models, including a rabbit VX2 carcinoma model, 181 a mouse model of hepatocellular carcinoma, 182 and head and neck squamous cell carcinoma
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H 2 O 2 oxidizes cysteine residues (Cys257, Cys268, and Cys568) on RIPK1, a process facilitating RIPK3 recruitment to the necrosome 70
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