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The district court sided with the FDA, reasoning that requiring notice-and-comment rulemaking for shortage determinations would render them stale before the ink dried

Its stability is noteworthy: unlike many bioactive peptides, BPC-157 remains intact in gastric acid for extended periods, which is why oral administration routes have been investigated alongside subcutaneous and intramuscular protocols

Peptides with particularly vulnerable amino acid sequences, especially those containing arginine or lysine residues at cleavage-susceptible positions, may be broken down before absorption occurs

10.1016/j.ijbiomac.2025.142173 52 HagymasiA