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Your body has partially readjusted to life without the medication, and restarting at your previous dose produces side effects similar to first starting treatment
For adults in the UK, the standard dietary reference intake is 1.5 micrograms (g) daily for maintenance of normal health
doi:10.2337/db16-0426 53
The fact that it can't be removed isn't a limitation
186 With respect to the specificity of Cu chelators, the use of trientine has been shown to inhibit the expression of IL-8 and exhibits anti-tumor effects in hepatocellular carcinoma
