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This schematic illustrates (left) the mechanism of action of edrophonium as a short-acting, reversible acetylcholinesterase (AChE) inhibitor that prevents acetylcholine breakdown at the neuromuscular junction
On the basis of this, we propose that under most conditions, SLC7A11 primarily exerts a tumor promoting effect, but its overexpression does expose an Achilles heel in cancer cells (by rendering them to be more sensitive to glucose or glutamine starvation)
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Lewis AD, Hayes JD, Wolf CR
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