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In mice lacking TREM2, fewer microglia accumulate in the corpus callosum during demyelination due to reduced proliferation which in turn reduces myelin debris clearance [200,201,202]

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Importantly, several phytochemicals demonstrate metabolic benefits by enhancing GLP-1/GIP signaling through DPP-IV inhibition, providing a biologically plausible route for synergistic neuroprotection in PD ( Therefore, future clinical strategies should investigate whether phytomolecules, either independently or in combination with GLP-1/incretin mimetics, can provide enhanced neuroprotection and improve both motor and non-motor outcomes in PD

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