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Studies on resistance development against anticancer thiosemicarbazones have underscored the importance of essential metal ions, including Fe(II), Cu(II), and Zn(II)(Psa et al

10.1016/j.semcdb.2019.01.005 [DOI] [PMC free article] [PubMed] [Google Scholar] Aoki M., Morishita R., Taniyama Y., Kida I., Moriguchi A., Matsumoto K., et al

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It should be noted that the fluctuations in GST activity may be caused by oxidative stress and the detoxification is induced by pollutant stimulation because the activity of GST could be activated to catalyze the binding of GSH with lipid peroxides or other harmful metabolites produced by oxidative damage and exert antioxidant and detoxification effects ( Doseresponse curve and one-way ANOVA were employed to obtain the EC 10/50 and the LOEC/NOEC of neonicotinoids, which revealed that the GST activity was promoted in zebrafish embryos at different temperatures ( Table 2 and Supplementary Figures S6FJ )

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